BCIG BRAINSTORMING SESSION: "Scientific Integrative Medicine: From Systems Biology to Disease Pathophysiology”

Clinical Center (Building 10) Medical Board Room (Room 2C116)

DESCRIPTION: (by David Goldstein) In a recent talk for the BCIG, I presented some of the concepts of scientific integrative medicine and computer models that can be applied to understand stress, allostatic load, and acute and chronic disorders. Now it is time to spur interest in working together to develop these models and more generally in introducing feedback-regulated systems into thinking about disease pathophysiology.

COMMENTARY: (by Jim DeLeo) I see this brainstorming session as an important event for launching a process (e.g. multidisciplinary extreme team) where computer and information scientists, statisticians, engineers and physicists can make significant contributions to clinical medicine by teaming with physicians like Dr. Goldstein to model the body’s “inner world.” I myself have a keen interest in exploring how systems dynamics (Jay Forrester) and modern network science (See Barabosi’s book “Linked”) might play a role here. If you have interest in this subject from any perspective, please come to this meeting and participate. BCIG Brainstorming sessions are conducted in an open, friendly and respectful manner. They are suitable for anyone interested in the subject matter.

NIH CONTACT: Jim DeLeo, 301-496-3848 jdeleo@nih.gov

BCIG WEB SITE: www.nih-bcig.org

NIH VISITOR INFORMATION: http://www.nih.gov/about/visitor/

3:00 pm to 4:30 pm September 7, 2006

FACILITATORS:

David Goldstein M.D., Ph.D., NINDS

David S. Goldstein M.D., Ph.D., Section Chief, Clinical Neurocardiology Section, Clinical Neurosciences Program, DIR, NINDS, NIH. Dr. Goldstein graduated from Yale College and received an MD-PhD from Johns Hopkins. After internal medicine training at the University of Washington, in 1978 he came to the NIH as a Clinical Associate in the National Heart, Lung, and Blood Institute, obtaining tenure as a Senior Investigator in 1984. He joined the NINDS in 1990 to lead the Clinical Neurochemistry Section. In 1999 he founded and since then has headed the Clinical Neurocardiology Section, an independent Section in the NINDS. He has received Yale’s Angier Prize for Research in Psychology, the Laufberger Medal of the Czech Academy of Sciences, the Presidential Executive Director’s Award of the National Dysautonomia Research Foundation, two NIH Merit Awards, and the NIH Distinguished Clinical Teacher Award. He is a Fellow of the American College of Physicians and of the American Heart Association and a Member of the American Society of Clinical Investigation, American Academy of Neurology, and American Physiological Society. He sits on the Executive Boards of the American Autonomic Society, the Association for Patient-Oriented Research, the Foundation for Catecholamine Research, and the Autonomic Nervous System Section of the American Academy of Neurology. He is the author of Stress, Catecholamines, and Cardiovascular Disease (1995), The Autonomic Nervous System in Health and Disease (2001), The NDRF Handbook for Patients with Dysautonomias (2002), and Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine (2006). His research on stress, catecholamine systems, dysautonomias, and clinical neurocardiologic disorders has been published in almost 450 papers, which have been cited more than 12,000 times. His main career goal is to use clinical laboratory assessments of catecholamine systems to introduce scientific integrative medicine into teaching, research, and clinical practice.