BCIG SPEAKER EVENT: "PharmGKB:
Is Sharing Pharmacogenomics Information Worthwhile?"
- view the seminar archive
Clinical
Center (Building 10) Medical Board Room (Room 2C116)
DESCRIPTION: The Pharmacogenetics & Pharmacogenomics Knowledgebase (PharmGKB,
http://www.pharmgkb.org/)is organizing pharmacogenomics information and
knowledge in a central location, in order to catalyze research innovation and
dissemination. It links to relevant external data resources, and provides core
search and visualization capabilities to assist investigators in accessing and
understanding relevant information. In order to achieve critical mass, PharmGKB
aims to identify and solicit high impact data sets relevant to pharmacogenomics,
and will organize, store, integrate and disseminate these data sets for analysis
by the community. The benefits of submission to PharmGKB include increased
community and funding-agency awareness of important results, accelerated
opportunities to identify useful collaborations, and recruitment of new
investigators to pharmacogenomics - particularly by creating an archival data
store that provides easy entry to those developing novel methods for analysis.
There are costs to submission that include the need to adopt standard formats,
the need to assign resources to the preparation of data submissions, and the
sharing of research data that still has potential value to the original
investigators. The "value proposition" for PharmGKB is that the benefits to
individual investigators (and the? biomedical research enterprise) of creating a
community that shares data in a central resource will outweigh the costs of
sharing data and knowledge in a new manner.
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3:00 - 4:30 pm March 16, 2006
Russ Biagio Altman, M.D., Ph.D.
Stanford University
SPEAKER: Russ Biagio Altman is professor of genetics,
bioengineering, & medicine (and of computer science by
courtesy) at Stanford University). His primary
research interests are in the application of computing
technology to basic molecular biological problems of
relevance to medicine. He is currently developing
techniques for collaborative scientific computation
over the Internet, including novel user interfaces to
biological data, particularly for pharmacogenomics
(e.g.
http://www.pharmgkb.org/ ). Other work focuses on
the analysis of functional microenvironments within
macromolecules and the application of algorithms for
determining the structure, dynamics and function of
biological macromolecules (e.g.
http://simbios.stanford.edu/ ). Dr. Altman holds
an M.D. from Stanford Medical School, a Ph.D. in
medical information sciences from Stanford, and an A.B.
from Harvard College. He has been the recipient of the
U.S. Presidential Early Career Award for Scientists
and Engineers, a National Science Foundation CAREER
Award. He is a fellow of the American College of
Physicians and the American College of Medical
Informatics. He is a past-president and founding board
member of the International Society for Computational
Biology, an organizer of the annual Pacific Symposium
on Biocomputing. He currently directs the Stanford
Center for Biomedical Computation, and he won the
Stanford Medical School graduate
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