BCIG TUTORIAL: "Effective
of Background Correction, Normalizsation and Summary Comparisons on the
Identification of Differentiating Expressed Transcripts in Microarray Analysis"
Clinical
Center (Building 10) Medical Board Room (Room 2C116)
- view the seminar archive
DESCRIPTION: Microarray
data preprocessing, such as differentially expressed
(DE) genes selection, is performed prior to higher level
statistical analysis in order to account for technical
variability. Preprocessing for the Affymetrix GeneChip
includes background correction, normalisation and
summarisation. Numerous preprocessing methods have been
proposed with little consensus as to which is the most
suitable. Furthermore, due to poor concordance among
results from cross-platform analyses, protocols are
being developed to enable cross-platform
reproducibility. In this talk I will discuss the results
of my analysis which had two objectives - first to
determine whether there is consistency in the results
obtained from a single platform; and second to
investigate the effect of preprocessing on DE genes
selection, analysed on four datasets.
REGISTRATION: As with all BCIG
events, registration is not required. Just show up
happy.
WEBCASTING: This event will be
web cast live and be made available for post program
viewing on the BCIG web site (www.nih-bcig.org).
To get more information about our webcasting service,
please contact Meeting Master Carl Leonard by e-mail:
cleonard@lired.com
or by calling him on 301-496-0191. NIH CONTACT: Jim
DeLeo, 301-496-3848,
jdeleo@nih.gov
REFRESHMENTS: Bring refreshments
if you would like. There is an open cafeteria near the
meeting room.
BCIG WEB SITE:
www.nih-bcig.org
NIH VISITOR INFORMATION:
http://www.nih.gov/about/visitor/
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3:00 - 4:30 pm September 14, 2006
Monika Ray, PhD
Washington University, St. Louis
SPEAKER: Monika Ray is
a PhD student at Washington University, St. Louis. Her
research interest is machine learning and data mining
with focus on biomedical applications. Her current
projects are related to Alzheimer's disease and
primary graft (lung) dysfunction.
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